HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 68681937, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Bromo-7-chloro-1H-indole-2-carboxylic acid | HCID 3292932 | — |
| Reactant | HCID 20444902 | HCID 20444902 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68681937 | HCID 68681937 | 89% |
Reaction Steps
The title compound was synthesized in analogy to example 1 from 5-bromo-7-chloro-1H-indole-2-carboxylic acid (commercially available), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (commercially available), 2,4-difluoro piperidine (commercially available) and N,N-diisopropylethylamine in N,N-dimethylformamide to give the desired product as a colorless foam (89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07723325B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-ff771ba3b3b542198639204e24ed2f48 |
| Source note | uspto-grants-2010_05 |