2-[6-(Dimethylamino)pyridin-3-yl]-1,3-benzoxazol-5-ol → 2-[2-(Dimethylamino)pyrimidin-5-yl]-1,3-benzoxazol-6-ol

HRID 2241810Notes

Reaction equation

HRID 2241810 reaction equation
C[O:2][C:3]1[CH:20]=[CH:19][C:6]2[N:7]=[C:8]([C:10]3[CH:11]=[N:12][C:13]([N:16]([CH3:18])[CH3:17])=[N:14][CH:15]=3)[O:9][C:5]=2[CH:4]=1.CN(C)C1N=CC(C2OC3C=CC(O)=CC=3N=2)=CC=1>>[CH3:17][N:16]([CH3:18])[C:13]1[N:14]=[CH:15][C:10]([C:8]2[O:9][C:5]3[CH:4]=[C:3]([OH:2])[CH:20]=[CH:19][C:6]=3[N:7]=2)=[CH:11][N:12]=1

Participants

3

Reactant 2

HCID 247806572-[6-(Dimethylamino)pyridin-3-yl]-1,3-benzoxazol-5-olHCID 247806585-(6-Methoxy-1,3-benzoxazol-2-yl)-N,N-dimethylpyrimidin-2-amine

Product 1

HCID 247806592-[2-(Dimethylamino)pyrimidin-5-yl]-1,3-benzoxazol-6-ol

Procedure

The title compound was synthesized from 5-(6-Methoxy-1,3-benzoxazol-2-yl)-N,N-dimethylpyrimidin-2-amine according to the general procedure as described for 2-[6-(dimethylamino)pyridin-3-yl]-1,3-benzoxazol-5-ol to give 30.3 mg: 1H NMR δ ppm 9.85 (br. s, 1H) 8.97 (s, 2H) 7.51 (d, 1H) 7.05 (d, 1H) 6.82 (dd, 1H) 3.22 (s, 6 H); MS m/z 257 (M+H).

Workup

  1. customto give 30.3 mg

Sources & evidence

ORD record
ord-9041c32433cb4ec0812e8ce02173e920
Source dataset
uspto-grants-2010_03
Patent number
US07670591B2

Reaction notes

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