5-Bromopyridine-2-carbaldehyde → HCID 24780662, compound

HRID 2241812Notes

Reaction equation

HRID 2241812 reaction equation
[Br:1][C:2]1N=C[C:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.BrC1[CH:21]=[N:22]C(C=O)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[N:22][CH:21]=1

Participants

3

Reactant 2

HCID 98775625-Bromopyridine-2-carbaldehydeHCID 24780660HCID 24780660, compound

Product 1

HCID 24780662HCID 24780662, compound

Procedure

The title compound was synthesized according to a procedure similar to that as described for 2-(6-bromopyridin-3-yl)-6-methoxy-1,3-benzoxazole starting from 3-bromo-6-formylpyridine to give 578.1 mg as an off white solid: 1H NMR δ ppm 8.91 (dd, 1H) 8.26-8.32 (m, 1H) 8.20 (dd, 1H) 7.75 (d, 1H) 7.46 (d, 1H) 7.06 (dd, 1H) 3.86 (s, 3 H); MS m/z 305, 307 (M+H, Bromo isotopes).

Workup

  1. customto give 578.1 mg as an off white solid

Sources & evidence

ORD record
ord-741f9ffd64d64197a7885be782156ccd
Source dataset
uspto-grants-2010_03
Patent number
US07670591B2

Reaction notes

Loading…