2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 24780801, compound

HRID 2241816Notes

Reaction equation

HRID 2241816 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([C:10]3[CH:11]=C[C:13]([NH2:16])=[N:14][CH:15]=3)[O:9][C:5]=2[CH:4]=1.[NH2:19]C1N=CC(B2OC(C)(C)C(C)(C)O2)=CN=1>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[N:14][C:13]([NH2:16])=[N:19][CH:11]=3)[O:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 24780799HCID 24780799, compound

Product 1

HCID 24780801HCID 24780801, compound

Procedure

The title compound was synthesised according to the procedure described for 5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-amine starting from 2-aminopyrimidine-5-boronic acid pinacol ester. 1H NMR δ ppm 8.89 (s, 2H) 7.61 (d, 1H) 7.48 (s, 2H) 7.37 (d, 1 H) 6.97 (dd, 1H) 3.83 (s, 3H); MS m/z 243 (M+H).

Sources & evidence

ORD record
ord-72b1b5393f0745059c9da28acff88efc
Source dataset
uspto-grants-2010_03
Patent number
US07670591B2

Reaction notes

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