HCID 24780801, compound → HCID 24781111, compound

HRID 2241817Notes

Reaction equation

HRID 2241817 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([C:10]3[CH:11]=[N:12][C:13]([NH2:16])=[N:14][CH:15]=3)[O:9][C:5]=2[CH:4]=1.COC1C=CC2N=C(C3C=CC(N[C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=NC=3)OC=2C=1>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[N:14][C:13]([NH:16][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[N:12][CH:11]=3)[O:9][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 24780801HCID 24780801, compoundHCID 24780959HCID 24780959, compound

Product 1

HCID 24781111HCID 24781111, compound

Procedure

The title intermediate was synthesized from 5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-amine according to the procedure described for tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate to give 115 mg. 1H NMR 400 MHz, Chloroform-d) δ ppm 9.33 (s, 2H) 8.17 (s, 1H) 7.65 (d, 1H) 7.14 (d, 1H) 7.00 (dd, 1 H) 3.90 (s, 3H) 1.60 (s, 9H). MS m/z 343 (M+H).

Workup

  1. customto give 115 mg

Sources & evidence

ORD record
ord-aaf3928a1d974a22bbba1517cecdc132
Source dataset
uspto-grants-2010_03
Patent number
US07670591B2

Reaction notes

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