HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → N-Benzyl-2,3-dibromomaleimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 1H-Pyrrole-2,5-dione, 3,4-dibromo-1-[(1,1-dimethylethyl)dimethylsilyl]- | HCID 10690418 | — |
| Reactant | HCID 178480630 | HCID 178480630 | — |
| Product | N-Benzyl-2,3-dibromomaleimide | HCID 3457221 | — |
| Product | HCID 178480630 | HCID 178480630 | — |
Reaction Steps
As depicted in Scheme I, bisbenzimidazolomaleimide (3) was synthesized in an economical fashion from readily available precursors in two steps by condensing deprotonated bisbenzimidazole (4) with N-TBDMS-2,3-dibromomaleimide (6a) followed by deprotection with TBAF to afford 3. Lactam 4 was obtained by condensing deprotonated bisbenzimidazole 5 with N-benzyl-2,3-dibromomaleimide 7, yielding 9, followed by a reduction and deprotection sequence, as shown in Scheme 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671046B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-669213711e004f6493d51356168b95c5 |
| Source note | uspto-grants-2010_03 |