Triethylamine → HCID 178513265, compound

Participants

Reaction Steps

199 mg of hydroxylammonium hydrochloride were added to a solution of 200 mg of {1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-2-yl}benzonitrile and 0.45 ml of triethylamine in 15 ml of isopropanol, and the mixture was stirred at room temperature for 12 h. The reaction solution was extracted twice with ethyl acetate/water. The organic phases were dried over magnesium sulfate and concentrated. This gave the product of molecular weight 451.48 (C25H23F2N3O3); MS (ESI): 452.10 (M+H+).

Provenance & Evidence