HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Cyanobenzal-p-anisidine → 1-(4-Aminomethylphenyl)-3-[3-hydroxy-3-phenylpropyl]-4-phenylazetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Cyanobenzal-p-anisidine | HCID 259759 | — |
| Reactant | 4-(Benzylideneamino)benzonitrile | HCID 262177 | — |
| Reactant | 3-[5-(4-Fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone | HCID 12111617 | — |
| Reactant | 3-(5-Hydroxy-5-phenylpentanoyl)-4-phenyl-1,3-oxazolidin-2-one | HCID 18374581 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 1-(4-Aminomethylphenyl)-3-[3-hydroxy-3-phenylpropyl]-4-phenylazetidin-2-one | HCID 21083170 | — |
Reaction Steps
Compound (16) was prepared as described in example IIIa-d, the differences being that: a) instead of 4-[(4-methoxyphenylimino)methyl]benzonitrile, 4-(benzylideneamino)benzonitrile was used, b) instead of 3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl-4-phenyloxazolidin-2-one, 3-[5-(phenyl)-5-hydroxypentanoyl]-4-phenyl-oxazolidin-2-one was used, and c) the product IIId was subjected to reduction with Raney nickel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671047B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-1fdd54ef934448c9b37143de1d16facc |
| Source note | uspto-grants-2010_03 |