Methyl 3-bromo-4-oxobutanoate → HCID 86588666, compound

HRID 2241880Notes

Reaction equation

HRID 2241880 reaction equation
[NH2:1][C:2]([NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[CH3:15])(=[O:7])=[O:6])=[S:3].Br[CH:17]([CH:23]=O)[CH2:18][C:19]([O:21][CH3:22])=[O:20]>N1C=CC=CC=1>[Cl:14][C:10]1[C:9]([CH3:15])=[C:8]([S:5]([NH:4][C:2]2[S:3][C:17]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:23][N:1]=2)(=[O:6])=[O:7])[CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 13948279Methyl 3-bromo-4-oxobutanoateHCID 21980189HCID 21980189, compound

Product 1

HCID 86588666HCID 86588666, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-(aminocarbonothioyl)-3-chloro-2-methylbenzenesulfonamide (0.4 g, 1.5 mmol) and methyl 3-bromo-4-oxobutanoate (0.3 g, 1.5 mmol), dissolved in pyridine (5 mL), were irradiated in a microwave oven for 2.5 min at 130° C. The solvent was removed under reduced pressure and the product separated from the starting materials using preparative HPLC (yield 0.2 g, 30%).

Workup

  1. customwere irradiated in a microwave oven for 2.5 min at 130° C
  2. customThe solvent was removed under reduced pressure
  3. customthe product separated from the starting materials

Sources & evidence

ORD record
ord-021c029bce1546fcbb08c4744d81a541
Source dataset
uspto-grants-2010_03
Patent number
US07671051B2

Reaction notes

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