HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2241896Generated: November 2, 2026
1,10-Phenanthroline → HCID 57462505, compound
https://huagongshe.com/reaction/2241896
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,10-Phenanthroline | HCID 1318 | — |
| Reactant | Cyclopentanol | HCID 7298 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 57424845 | HCID 57424845 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | HCID 57462505 | HCID 57462505 | — |
Reaction Steps
A microwave vial was charged with (R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one, cesium carbonate (2 eq), copper (I) iodide (10 mol %), 1,10-phenanthroline (20 mol %), and cyclopentanol. The reaction mixture was heated with microwave irradiation to a temperature of 180° C. for 20 min. After cooling to RT, the reactionmixture was concentrated and purified by reverse phase HPLC to afford (R)-2-amino-7-(2-(cyclopentyloxy)-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (m/z=357 (M+H)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07671059B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-83614e75df9646ecbd7d321b93590249 |
|---|
| Source note | uspto-grants-2010_03 |
|---|
