Water → 2-{2-[1-(2-Fluoro-4-nitrophenyl)piperidin-4-yl]ethyl}isoindoline-1,3-dione

Participants

Reaction Conditions

Reaction Steps

Potassium phthalimide (0.580 g, 4.68 mmol) was added to a solution of toluene-4-sulfonic acid 2-[1-(2-fluoro-4-nitrophenyl)piperidin-4-yl]ethyl ester (compound of Reference Example 65; 0.661 g, 1.56 mmol) in N,N-dimethylformamide (10 ml), and the mixture was stirred at 80° C. for 1 hour. Water was added to the reaction mixture, and the precipitated solid was collected by filtration and washed with water to give the title compound (0.577 g, 93%) as a yellow solid.

Provenance & Evidence