Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | HCID 59204940 | HCID 59204940 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59204906 | HCID 59204906 | 72% |
Reaction Steps
4-Pyridineboronic acid (0.185 mg, 1.51 mmol), potassium carbonate (0.240 g, 1.74 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1:1) (0.189 g, 0.232 mmol) and water (0.5 ml) were added to a solution of N-(4-bromo-3-fluorophenyl)-5-chloro-2-hydroxybenzamide (compound of Reference Example 185; 0.400 g, 1.16 mmol) in dioxane (5 ml), and the mixture was stirred at 80° C. for 2 hours. Water was added to the reaction mixture, and the precipitated solid was collected by filtration and washed with acetone and dichloromethane to give the title compound (0.286 g, 72%) as a light grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07671058B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-4cbc159dcd8d4054b5fe0b38b112e2b6 |
|---|
| Source note | uspto-grants-2010_03 |
|---|
