Hydrogen chloride-ethyl acetate → HCID 23634420, compound

Participants

Reaction Steps

4N Hydrogen chloride/ethyl acetate solution (10.0 ml, 40.0 mmol) was added to a solution of (1-{4-[5-chloro-2-(2-methoxyethoxymethoxy)benzoylamino]-2-fluorophenyl}piperidin-4-yl)carbamic acid tert-butyl ester (compound of Reference Example 143; 0.15 g, 0.271 mmol) in ethyl acetate (2 ml) under ice cooling, and the mixture was stirred at room temperature for 3 hours. The precipitated crystal was collected by filtration and washed with ethyl acetate to give the title compound (0.10 g, 93%) as a colorless crystal.

Provenance & Evidence