Hydrochloric Acid → HCID 68546719, compound

Participants

Reaction Steps

Sodium borohydride (0.038 g, 1.00 mmol) was added to a solution of 5-chloro-N-{3-fluoro-4-[4-(2-oxopropan-1-yl)piperazin-1-yl]phenyl}-2-(2-methoxyethoxy methoxy)benzamide (compound of Reference Example 144; 0.134 g, 0.272 mmol) in methanol (1 ml) under ice cooling, and the mixture was stirred at room temperature for 1 hour. 0.5N Hydrochloric acid was added to the reaction mixture, and the mixture was concentrated under reduced pressure. The precipitated solid was collected by filtration and washed with water. 2N Hydrochloric acid was added to the obtained solid, and the mixture was refluxed for 1 hour. The reaction mixture was cooled to room temperature, and the precipitated solid was collected by filtration and washed with acetone to give the title compound (0.113 g, 93%) as a white solid.

Provenance & Evidence