Potassium Hydroxide → HCID 68547061, compound

Participants

Reaction Steps

Hydrazine monohydrate (0.227 ml, 5.70 mmol) and potassium hydroxide (0.641 g, 11.4 mmol) were added to a solution of 4-{[4-(5-chloro-2-hydroxybenzoylamino)-2-fluorophenyl]amino}piperidine-1-carboxylic acid ethyl ester (compound of Reference Example 189; 0.500 g, 1.14 mmol) in ethyleneglycol (10 ml), and the mixture was refluxed for 1 hour. The reaction mixture was cooled to room temperature, and saturated aqueous ammonium chloride and water were added. The precipitated solid was collected by filtration and washed with water to give the title compound (0.267 g, 64%) as an ivory solid.

Provenance & Evidence