Ethyl Acetate → 5-[3-[(1S)-2-(Difluoromethoxy)-1-methylethoxy]-5-[[(5-methyl-2-pyrazinyl)amino]carbonyl]phenoxy]-N,N-dimethyl-2-pyrazinecarboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[(2S)-1-(difluoromethoxy)propan-2-yl]oxy-5-hydroxy-N-(5-methylpyrazin-2-yl)benzamide (0.19 g, 0.54 mmol), 5-chloro-N,N-dimethyl-pyrazine-2-carboxamide (100 mg, 0.54 mmol) and potassium carbonate (149 mg, 1.08 mmol) in acetonitrile (5 mL) was stirred in a microwave reactor at 140° C. for 5 hours and the mixture reduced in vacuo. Ethyl acetate (50 mL) was added and the mixture washed with water (50 mL), brine (50 mL), dried (MgSO4), and reduced in vacuo. The crude residue was chromatographed on silica, eluting with 0-5% methanol in DCM, to give the desired compound (150 mg).

Provenance & Evidence