HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Bromo-6-chloroquinoline → 1-(6-Chloro-8-quinolinyl)-4-piperidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Bromo-6-chloroquinoline | HCID 21818213 | — |
| Reactant | 1-Quinolin-8-yl-piperidin-4-one | HCID 59204842 | — |
| Product | 1-(6-Chloro-8-quinolinyl)-4-piperidinone | HCID 59204844 | — |
Reaction Steps
This compound was prepared from the known 8-bromo-6-chloroquinoline (Lachowicz et al., Rocz. Chem., 40:1848 (1966)) using a synthetic sequence and reagents identical to those described for the synthesis of 1-quinolin-8-yl-piperidin-4-one (Step 5, Example A, above). The compound was obtained as an off-white solid; MP: 223-225° C.; MS (ES) m/z (relative intensity): 261 (M+H)+ (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671056B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-410a0d60cd1244209318ed2d06be95c7 |
| Source note | uspto-grants-2010_03 |