HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium triacetoxyborohydride → 8-{4-[1-(8-Quinolinyl)-4-piperidinyl]-1-piperazinyl}-5-(trifluoromethyl)-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-Quinolin-8-yl-piperidin-4-one | HCID 59204842 | — |
| Reactant | 8-(1-Piperazinyl)-5-(trifluoromethyl)quinoline | HCID 59204847 | — |
| Product | 8-{4-[1-(8-Quinolinyl)-4-piperidinyl]-1-piperazinyl}-5-(trifluoromethyl)-quinoline | HCID 12004170 | — |
Reaction Steps
Using the synthetic methods described in previous examples, 5-(trifluoromethyl)-8-(piperazin-1-yl)quinoline (Step 3) and 1-quinolin-8-yl-piperidin-4-one (Example A, Step 5, above) were reacted with sodium triacetoxyborohydride to give the desired product as a white solid; MP. 202-204° C.; MS (ES) m/z (relative intensity) 492 (M+H)+ (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671056B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-245cc2ac129040f48d4680b339379c5a |
| Source note | uspto-grants-2010_03 |