Hydrochloric Acid → HCID 68434681, compound

Participants

Reaction Conditions

Reaction Steps

Solid lithium hydroxide (20 eq) was added to a stirred solution of 1-{3-[(6-amino-5-nitro(2-pyridyl))amino]propyl}-4-(2,4-dichlorophenyl)pyrrole-2-carboxylate (10) (1 eq) in THF and water at rt. The mixture was heated to 50° C. for 12 h until complete by LC/MS. The reaction was allowed to cool to room temperature and acidified with 1 M HCl (aq.). The acidic solution was extracted with EtOAc. The combined organic layers were dried (Na2SO4), filtered, and concentrated to pure 1-{3-[(6-amino-5-nitro(2-pyridyl))amino]propyl}-4-(2,4-dichlorophenyl)pyrrole-2-carboxylic acid (11) as a sticky yellow solid (99% yield).

Provenance & Evidence