HCID 22324048, compound → HCID 59205153, compound

HRID 2242029Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][CH2:8][O:9][C:4]=2[C:3]=1[S:12]([NH2:15])(=[O:14])=[O:13].Cl[C:17]1[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]2[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=2)[N:18]=1>O1CCOCC1>[CH3:35][O:34][C:26]1[CH:25]=[C:24]([NH:23][C:19]2[N:18]=[C:17]([NH:1][C:2]3[CH:11]=[CH:10][C:5]4[O:6][CH2:7][CH2:8][O:9][C:4]=4[C:3]=3[S:12]([NH2:15])(=[O:14])=[O:13])[CH:22]=[CH:21][N:20]=2)[CH:29]=[C:28]([O:30][CH3:31])[C:27]=1[O:32][CH3:33]

Participants

Conditions

Temperature: 120 °C

Procedure

6-Amino-2,3-dihydro-benzo[1,4]dioxine-5-sulfonic acid amide (87 mg, 0.38 mmol) and (4-chloro-pyrimidin-2-yl)-(3,4,5-trimethoxy-phenyl)-amine (112 mg, 0.38 mmol) are dissolved in dioxane (1.3 ml). The mixture is heated to 120° C. for 1 h. The reaction mixture is purified by repeated chromatography on silica gel using different solvent mixture, yielding 6-[2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,3-dihydro-benzo[1,4]dioxine-5-sulfonic acid amide.

Workup

customThe reaction mixture is purified

Sources & evidence

ORD record: ord-38f15b69c1474ed2b5dce2571f9cb4d0
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07671063B2

Reaction notes

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