Dimethyl Sulfoxide → HCID 66916056, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-6-nitro-benzenesulfonamide (500 mg, 2.10 mmol), DMSO (3 ml), diethyl amine (10 ml of 2 M solution in THF), Bu4NHSO4 (34 mg, 0.1 mmol) and KF (58 mg, 1.0 mmol) is heated in an autoclave at 70° C. for 16 h. The mixture is diluted with water and extracted with CH2Cl2. The solvent is removed and the residue subjected to chromatography (SiO2, TBME/cyclohexane 1:9→TBME) to give 2-dimethylamino-6-nitro-benzenesulfonamide as a colorless solid.

Provenance & Evidence