HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2242037Generated: November 2, 2026
3,4-dihydro-2H-pyran → HCID 11011298, compound
https://huagongshe.com/reaction/2242037
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 4186956 | HCID 4186956 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11011298 | HCID 11011298 | — |
Reaction Steps
N-(3-Hydroxy-phenyl)-2,2-dimethyl-propionamide (49 g, 0.254 mol) in dichloromethane (1 l) is treated with dihydropyrane (66 ml, 0.762 mol) and pyridinium p-toluenesulfonate (957 mg, 3.8 mmol). After stirring for 6 days at 25° C., the solvent is removed and the residue crystallized from EtOAc/hexanes to give 2,2-dimethyl-N-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-propionamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07671063B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-492cdfd7581449cd927ab9a3366558cb |
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| Source note | uspto-grants-2010_03 |
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