Methanesulfonic Acid → HCID 66916062, compound

Participants

Reaction Steps

To a solution of 2,2-dimethyl-N-[2-sulfamoyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-propionamide (21.9 g, 61.5 mmol) in methanol (220 ml) a solution of methanesulfonic acid (11 ml) in methanol (10 ml) is added within 4 min at 25° C. After stirring for 1 h, the solvent is removed. The residue is partitioned between water and EtOAc. After washings with water, 10% NaHCO3, and brine, evaporation of the dried (Na2SO4) organic phase gave N-(3-hydroxy-2-sulfamoyl-phenyl)-2,2-dimethyl-propionamide.

Provenance & Evidence