HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2242043Generated: October 25, 2026
Hydrochloric Acid → 2-Nitro-6-(trifluoromethoxy)aniline
https://huagongshe.com/reaction/2242043
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazinium, 1,1,1-trimethyl-, iodide (1:1) | HCID 18683 | — |
| Reactant | 1-Nitro-3-(trifluoromethoxy)benzene | HCID 2777297 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Nitro-6-(trifluoromethoxy)aniline | HCID 66915944 | — |
Reaction Steps
To a solution of 3-trifluoromethoxy nitrobenzene (4.0 g, 20 mmol) in DMSO (60 ml), trimethylhydrazinium iodide (4.4 g, 22 mmol) is added and cooled to 0° C. KOt-Bu is added in portions. After stirring for 4 h at 25° C., ice water is added, pH is adjusted to 2-3 with HCl solution, the mixture extracted with EtOAc and washed with brine, followed by drying (Na2SO4) and evaporation of the solvent. Chromatography (silica gel, CH2Cl2/hexane=1:1) gave 2-nitro-6-trifluoromethoxy-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07671063B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-bd5239cbbae9487da39605c7ff37aac0 |
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| Source note | uspto-grants-2010_03 |
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