HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → N-Benzyl-N,2-dimethyl-5-nitro-aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,2-dimethyl-5-nitroaniline | HCID 13317617 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-Benzyl-N,2-dimethyl-5-nitro-aniline | HCID 66915963 | — |
Reaction Steps
K2CO3 (270 mg) is added to a solution of N,2-dimethyl-5-nitro-aniline (214.5 mg, 1.29 mmol) and benzyl bromide (0.2 mL, 1.7 mmol) in DMF (4 mL). The mixture is heated for 12 h to 70° C. under stirring. Volatiles are evaporated at reduced pressure. Chromatography of the residue (silica gel, hexane/EtOAc 4:1) yields N-Benzyl-N,2-dimethyl-5-nitro-aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671063B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-638d1cac3ebc4de3b759fa707561bbde |
| Source note | uspto-grants-2010_03 |