Thionyl Chloride → 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride

Participants

Reaction Steps

Thionyl chloride (25 ml, 344 mmol) was added dropwise to a solution of 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid (12 g, 48 mmol) in toluene (100 ml) and the reaction mixture was heated to reflux for 2 hours, then the solvent was evaporated to dryness under vacuum and the residue was used without further purification (13.2 g, 48 mmol, 100% yield).

Provenance & Evidence