Fexofenadine → Fexofenadine Hydrochloride

Participants

Reaction Steps

Fexofenadine free base (20 grams) was crushed and put into a 250 ml round bottom flask in an ice bath with a magnetic stirrer. HCl/IPA (6.5 ml) was added to 80 ml methanol and cooled in an ice bath, and then added to the flask with mixing. After 15 minutes, the flask was filtered, and the filtrate evaporated off at room temperature first with a water aspirator then with a diaphragm pump and finally with an oil pump. The remaining material (5 grams) was stirred as a slurry overnight with a mixture of heptane (15 ml) and methanol (1.5 ml), filtered and dried for 1 hour at 65° C. under vacuum. PXRD analysis confirmed presence of Form XVI of fexofenadine hydrochloride.

Provenance & Evidence