Sodium borohydride → HCID 11668580, compound

Participants

Reaction Steps

4-(5-Formyl-2-methoxy-phenyl)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester (30 mg, 0.074 mmol) was dissolved in ethanol (1 mL) and treated with sodium borohydride (26 mg) in one portion. After stirring at room temperature for 15 min, the reaction mixture was quenched with an aqueous solution of ammonium chloride. The reaction mixture was then extracted with ethyl acetate and the organic layer was dried over sodium sulfate, concentrated. The crude compound was purified by column chromatography eluted with 30% ethyl acetate to yield 4-(5-hydroxymethyl-2-methoxy-phenyl)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester as a white solid.

Provenance & Evidence