3-(3-Formyl-pyridin-4-yl)-benzonitrile → HCID 59205204, compound

Participants

Reaction Steps

To a solution of 3-(3-formyl-pyridin-4-yl)-benzonitrile (21 mg, 0.1 mmol) in THF (1 mL) at −78° C. was added 3.0 M phenylmagnesium bromide in THF (0.1 mL). The reaction mixture was quenched with ammonium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, concentrated, and the residue purified by flash chromatography to yield 3-[3-(hydroxy-phenyl-methyl)-pyridin-4-yl]-benzonitrile as a colorless oil.

Provenance & Evidence