3-(3-Formyl-pyridin-4-yl)-benzonitrile → 3-{3-[Hydroxy-(4-methoxy-phenyl)-methyl]-pyridin-4-yl)-benzonitrile

Participants

Reaction Steps

To the solution of 3-(3-formyl-pyridin-4-yl)-benzonitrile (30 mg, 0.15 mmol) in THF (1.5 mL) at −78° C. was added 0.5 M 4-methoxyphenylmagnesium bromide in THF (0.6 mL). The reaction mixture was quenched with ammonium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, concentrated, and the residue purified by flash chromatography eluted with 5% methanol in dichloromethane to yield 3-{3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyridin-4-yl}-benzonitrile as white crystals.

Provenance & Evidence