1,4-Dioxane → HCID 59205222, compound

Participants

Reaction Steps

A flask was with charged 4-bromo-pyridine-3-carbaldehyde (376 mg, 2 mmol), 3-formal-6-methoxyphenelboronic acid (432 mg, 2.4 mmol), tetrakis(triphenylphosphine) palladium(0) (116 mg, 0.1 mmol), potassium phosphate (638 mg, 3 mmol) and 1,4-dioxane (20 mL). The reaction mixture was kept at 80° C. overnight, then diluted with ethyl acetate and washed with water then brine. The organic layer was dried over sodium sulfate, concentrated, and the residue purified by flash chromatography to yield 3-(3-hydroxymethyl-pyridin-4-yl)-4-methoxy-benzaldehyde as a yellow oil.

Provenance & Evidence