4-Toluenesulfonyl chloride → HCID 11528667, compound

Participants

Reaction Steps

3-[Hydroxy-(3-hydroxymethyl-pyridin-4-yl)-methyl]-benzonitrile (100 mg, 0.42 mmol) and tosyl chloride (96 mg, 0.50 mmol) were dissolved in dichloromethane (5 mL) and then the reaction mixture was treated with triethylamine (0.09 mL, 0.65 mmol). The reaction mixture was stirred overnight at room temperature, then diluted with ethyl acetate and washed with 5% sodium bicarbonate. The organic layer was dried over sodium sulfate, concentrated, and the residue purified by chromatography of silica gel with 30% ethyl acetate in hexane to yield 3-(1,3-dihydro-furo[3,4-c]pyridin-1-yl)-benzonitrile as a white solid.

Provenance & Evidence