Acetic Acid → HCID 68548621, compound

Participants

Reaction Steps

The above crude 3-dimethylamino-2-(5-methyl-2-nitro-benzoyl)-acrylic acid ethyl ester j (3.06 g, 10 mmol) and the hydrazino-acetic acid ethyl ester hydro chloride (1.64 g, 10 mmol) were refluxed in absolute ethanol containing catalytic amount of acetic acid for 8 h. The reaction mixture was cooled and concentrated in vacuo. The residue was purified by column chromatography to provide pure compound 1 (1.81 g, 50% yield for two steps): LC MS (Method B): 362 (M+1).

Provenance & Evidence