Hydrochloric Acid → HCID 178523393, compound

Participants

Reaction Steps

To a solution of Example 30B (292.8 mg, 0.6 mmol) dissolved in methanol (10 mL) was added a solution of 4N HCl in dioxane (1.5 mL, 4 M, 6 mmol) via syringe at room temperature. The mixture was allowed to stir for 12 hours at room temperature, concentrated under reduced pressure to provide the titled compound. MS (ESI) m/e 388 (M+H)+, 386 (M−H)−; 1H NMR (500 MHz, CD3OD) δ ppm 1.97 (m, 1 H) 2.86 (m, 2 H) 3.16 (m, 2 H) 3.39 (m, 1 H) 3.61 (s, 2 H) 3.69 (m, 1 H) 3.76 (s, 2H) 3.97 (m, 1 H) 4.53 (m, 2 H) 7.69 (m, 1 H) 8.07 (m, 1 H) 8.20 (m, 1 H) 8.57 (s, 1 H).

Provenance & Evidence