Methanesulfonamide → HCID 47269479, compound

Participants

Reaction Steps

To a mixture of isophthalic acid monomethyl ester (500.0 mg, 2.8 mmol), methanesulfonamide (340 mg, 3.6 mmol) and DMAP (440 mg, 3.6 mmol) in anhydrous dichloromethane (30 mL) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (690 mg, 3.6 mmol). The mixture was allowed to stir for 12 hours at room temperature and then concentrated under reduced pressure. The residue was chromatographed on a Biotage 40M eluting with 2% methanol/98% dichloromethane to provide the titled compound. MS (EST) m/e 259 (M+H)+, 257 (M−H)−; 1H NMR (300 MHz, CD3OD) δ ppm 3.36 (s, 3 H) 3.95 (s, 3 H) 7.64 (t, J=7.80 Hz, 1 H) 8.13 (dd, J=7.80, 1.36 Hz, 1 H) 8.25 (m, 1 H) 8.55 (m, 1 H).

Provenance & Evidence