5-Chloropyrimidine-2-carbonitrile → 5-Chloro-2-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrimidine

HRID 2242215Notes

Reaction equation

HRID 2242215 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.ClC1C=CC(C2[N:21]=[C:20]([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=3)[O:19]N=2)=CN=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[N:21]=[C:20]([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=3)[O:19][N:9]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 8201985-Chloropyrimidine-2-carbonitrileHCID 592042672-Chloro-5-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]pyridine

Product 1

HCID 592043135-Chloro-2-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrimidine

Procedure

The title compound was prepared from 5-chloropyrimidine-2-carbonitrile by procedures analogous to those described in Example 4A-4B for the preparation of 2-Chloro-5-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]pyridine.

Sources & evidence

ORD record
ord-3349f5e4bf1746b9b65a98884dfe0ccc
Source dataset
uspto-grants-2010_03
Patent number
US07671043B2

Reaction notes

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