4-Isobutylbenzoic acid → 4-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-benzoic acid methyl ester

HRID 2242241Notes

Reaction equation

HRID 2242241 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[N:11])=[C:6]([CH3:12])[CH:5]=1.[CH2:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=1)[CH:15]([CH3:17])[CH3:16].O[NH:28]C(=N)C1C=CC(CO)=CC=1.C(OC1C=CC(C2ON=C(C3C=CC(CO)=CC=3)N=2)=CC=1)(C)C>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:28]=[C:22]([C:21]3[CH:25]=[CH:26][C:18]([CH2:14][CH:15]([CH3:17])[CH3:16])=[CH:19][CH:20]=3)[O:23][N:11]=2)=[C:6]([CH3:12])[CH:5]=1

Participants

5

Reactant 4

HCID 381114-Isobutylbenzoic acidHCID 19969932Methyl 4-cyano-3-methylbenzoateHCID 592043064-[5-(4-Isopropoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-phenylmethanol2×HCID 178513316HCID 178513316, compound2×

Product 1

HCID 592043164-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-benzoic acid methyl ester

Procedure

The title compound was prepared from 4-cyano-3-methyl-benzoic acid methyl ester and 4-isobutyl-benzoic acid by procedures analogous to those described in Preparations 8B and 10A for the preparation of N-hydroxy-4-hydroxymethyl-benzamidine and 4-[5-(4-isopropoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-phenylmethanol, respectively.

Sources & evidence

ORD record
ord-d764a45c9d41437b9aef95d501f859d4
Source dataset
uspto-grants-2010_03
Patent number
US07671043B2

Reaction notes

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