{3-[5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methanol → 3-[5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl]benzaldehyde

Participants

Reaction Steps

Florosil (400 mg) and pyridinium chlorochromate (195 mg, 0.903 mmol) were added to a solution of {3-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]phenyl}methanol (139 mg, 0.451 mmol) and methylene chloride (2.5 mL) and stirred at ambient temperature for 3 hours. The reaction mixture was filtered through a pad of silica gel. The pad was rinsed with methylene chloride (2×) and 1:1 ethyl acetate:hexanes (2×). The filtrate was concentrated in vacuo to give the desired compound as a crude residue.

Provenance & Evidence