3-({5-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrazin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acid → HCID 178440784, compound

HRID 2242251Notes

Reaction equation

HRID 2242251 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=3)=[N:11][N:12]=2)=[CH:4][N:3]=1.C(C1C=CC(C2ON=C(C3C=CC(C=O)=NC=3)N=2)=CC=1)C(C)C.C(C1C=CC(C2ON=C(C3N=CC([CH2:67][NH:68][CH:69]4[CH2:72][CH:71]([C:73]([OH:75])=[O:74])[CH2:70]4)=NC=3)N=2)=CC=1)C(C)C>>[CH2:19]([C:16]1[CH:17]=[CH:18][C:13]([C:10]2[O:9][C:8]([C:5]3[CH:6]=[CH:7][C:2]([CH2:67][NH:68][C@@H:69]4[CH2:72][C@H:71]([C:73]([OH:75])=[O:74])[CH2:70]4)=[N:3][CH:4]=3)=[N:12][N:11]=2)=[CH:14][CH:15]=1)[CH:20]([CH3:22])[CH3:21]

Participants

4

Reactant 3

HCID 177573723-({5-[5-(4-Isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrazin-2-ylmethyl}-amino)-cis-cyclobutanecarboxylic acidHCID 592042725-[5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl]pyridine-2-carbaldehydeHCID 592042812-Chloro-5-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]pyridine

Product 1

HCID 178440784HCID 178440784, compound

Procedure

The title compound was prepared from 2-chloro-5-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]pyridine by procedures analogous to those described in Preparations (5C-5D) and Examples (1A-1B) for the preparation of 5-[5-(4-isobutylphenyl)-1,2,4-oxadiazol-3-yl]pyridine-2-carbaldehyde and 3-({5-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrazin-2-ylmethyl}-amino)-cyclobutanecarboxylic acid, respectively.

Sources & evidence

ORD record
ord-f6a90ea11960471194f213d2c6d4de4a
Source dataset
uspto-grants-2010_03
Patent number
US07671043B2

Reaction notes

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