反应详情

温度

45 °C

A solution of 4M aqueous sodium hydroxide (0.29 ml) was added to a solution of 5-chloro-1-(3-methylbenzyl)-1H-indole-2-carboxylic acid ethyl ester (2.90 g, 8.85 mmol) in ethanol (30 ml) and the reaction heated at 45° C. for 3 h. After concentrating the mixture to 5 ml, a solution of 2M aqueous HCl (2 ml) was added to precipitate the product as a pale solid which was filtered, washed with water (3×30 ml) and dried under vacuum, to afford 5-chloro-1-(3-methylbenzyl)-1H-indole-2-carboxylic acid (2.57 g, 89%).

1. concentrationAfter concentrating the mixture to 5 ml
2. additiona solution of 2M aqueous HCl (2 ml) was added
3. customto precipitate the product as a pale solid which
4. filtrationwas filtered
5. washwashed with water (3×30 ml)
6. customdried under vacuum