反应详情

温度

45 °C

A solution of 4M aqueous sodium hydroxide (1.10 ml) was added to a solution of 1-(5-tert-butyl-2-methoxybenzyl)-5-chloro-1H-indole-2-carboxylic acid ethyl ester (1.13 g, 2.82 mmol) in ethanol (15 ml) and the reaction heated at 45° C. for 3 h. After concentrating the mixture to 5.0 ml, a solution of 2M aqueous HCl (2.0 ml) was added to precipitate the product as a pale solid which was filtered, washed with water (3×30 ml) and dried under vacuum, affording 1-(5-tert-butyl-2-methoxybenzyl)-5-chloro-1H-indole-2-carboxylic acid (1.03 g, 2.77 mmol, 98%).

1. concentrationAfter concentrating the mixture to 5.0 ml
2. additiona solution of 2M aqueous HCl (2.0 ml) was added
3. customto precipitate the product as a pale solid which
4. filtrationwas filtered
5. washwashed with water (3×30 ml)
6. customdried under vacuum