HCID 24729719, compound → HCID 59205450, compound

HRID 2242365Notes

Reaction equation

HRID 2242365 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24]([OH:26])=O)=[CH:6]2)#[N:2].[NH2:27][CH:28]([CH:32]1[CH2:34][CH2:33]1)[CH2:29][CH2:30][OH:31]>>[CH:32]1([CH:28]([NH:27][C:24]([C:7]2[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:22])([F:21])[F:23])[CH:14]=3)[C:9]3[C:5]([CH:6]=2)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=3)=[O:26])[CH2:29][CH2:30][OH:31])[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 24729719HCID 24729719, compoundHCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 59205450HCID 59205450, compound

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and 3-amino-3-cyclopropylpropan-1-ol in a manner similar to that described in Example 11.

Sources & evidence

ORD record
ord-0c398ea4d3834ab8a1c5b1eb425b0f5c
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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