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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2242383Generated: November 1, 2026

Ethyl cyanoacetate → ethyl 1-cyanocyclobutanecarboxylate

https://huagongshe.com/reaction/2242383

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl cyanoacetateHCID 7764—
Reactant1,3-DibromopropaneHCID 8001—
ReactantEthyl 1-cyanocyclopentane-1-carboxylateHCID 15688760—
Productethyl 1-cyanocyclobutanecarboxylateHCID 27534367%

Reaction Steps

1-Cyano-cyclobutanecarboxylic acid ethyl ester was prepared from ethyl cyanoacetate (10.0 g, 88.4 mmol) and 1,3-dibromopropane (8.9 ml, 88.5 mmol) in the same manner as 1-cyano-cyclopentanecarboxylic acid ethyl ester giving 1-cyano-cyclobutanecarboxylic acid ethyl ester as a yellow oil (9.03 g, 67%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07671080B2
Source datasetuspto-grants-2010_03
ORD IDord-d131af1f64c641d999c708c46764bb30
Source noteuspto-grants-2010_03