HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxymethyicyclopentylmethyl)amide → HCID 68551094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxymethyicyclopentylmethyl)amide | HCID 24890015 | — |
| Reactant | Ethyl 1-(aminomethyl)cyclobutanecarboxylate | HCID 45122079 | — |
| Reactant | 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid | HCID 68543106 | — |
| Product | HCID 68551094 | HCID 68551094 | 52.2% |
Reaction Steps
1-({[5-Cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carbonyl]amino}methyl)-cyclobutanecarboxylic acid ethyl ester was prepared from 1-aminomethyl-cyclobutanecarboxylic acid ethyl ester (262 mg, 1.65 mmol) and 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (400 mg, 1.10 mmol) in the same manner as 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (1-hydroxymethyl-cyclopentylmethyl)amide giving 1-({[5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carbonyl]amino}methyl)cyclobutanecarboxylic acid ethyl ester as a colourless gum (287 mg, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671080B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-4c89a782087e45c3a28754416f233900 |
| Source note | uspto-grants-2010_03 |