Ethanol → Ethyl 3-amino-2-methylpropanoate hydrochloride
Reaction equation
[NH2:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].S(Cl)([Cl:10])=O.[CH2:12](O)[CH3:13]>C(Cl)Cl>[ClH:10].[CH2:12]([O:5][C:4](=[O:6])[CH:3]([CH3:7])[CH2:2][NH2:1])[CH3:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
3-Aminoisobutyric acid (1.00 g, 9.7 mmol) was stirred in DCM under nitrogen and thionyl chloride (1.4 ml, 19.4 mmol) was added at room temperature. The reaction was heated to 50° C. for 2 h. The solvent and any excess thionyl chloride were removed under reduced pressure and the oil obtained was dissolved in ethanol (20 ml) stirring at room temperature for 18 h. The solvent was removed under reduced pressure to give 3-aminoisobutyric acid ethyl ester hydrochloride as a viscous, cloudy oil (1.47 g, 90%).
Workup
- customThe solvent and any excess thionyl chloride were removed under reduced pressure
- customthe oil obtained
- customThe solvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-6b0fbca56b8d462aa450a7993f682fa6
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07671080B2
Reaction notes
Loading…