4,4,4-Trifluoro-3-hydroxy-3-methylbutanoic acid → 3-(Trifluoromethyl)-3-hydroxybutyric acid methyl ester

Participants

Reaction Steps

To a solution of 4,4,4-trifluoro-3-hydroxy-3-methylbutyric acid (1.81 g, 10.0 mmol) in methanol (10 ml) was added (trimethylsilyl)diazomethane (10 ml), dropwise. The reaction was then stirred at room temperature for 4 h. Removal of the solvent afforded the crude 3-(trifluoromethyl)-3-hydroxybutyric acid methyl ester as a yellow oil (1.92 g, 100%).

Provenance & Evidence