反应详情

To a cold solution (−30° C.) of 2 (3.18 g, 16.1 mmol) dissolved in MeOH (23 mL), NaBH4 (0.66 g, 17.5 mmol) was added. After nine minutes the excess of NaBH4 was destroyed by adding brine (80 mL). The mixture was concentrated and extracted with ethyl acetate (4×80 mL). The organic phases were dried, filtrated and concentrated and gave 3 (3.0 g, 92%) as a yellow oil.

1. customAfter nine minutes the excess of NaBH4 was destroyed
2. additionby adding brine (80 mL)
3. concentrationThe mixture was concentrated
4. extractionextracted with ethyl acetate (4×80 mL)
5. customThe organic phases were dried
6. filtrationfiltrated
7. concentrationconcentrated