HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Boc-Chg-Ome
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Aluminum | HCID 5359268 | — |
| Reactant | N-(tert-Butoxycarbonyl)-L-cyclohexylglycine | HCID 7004938 | — |
| Catalyst | HCID 178418778 | HCID 178418778 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Boc-Chg-Ome | HCID 13773589 | 100.2% |
Reaction Steps
To a solution of Boc-Chg-OH (53 mg, 0.206 mmol) in acetone (3 mL) were added methyl iodide (195 μL, 3.1 mmol) and silver (I) oxide (53 mg, 0.229 mmol). The mixture was allowed to stir over night in a reaction flask that was covered with aluminium foil. Thereafter the solution was filtered through celite and evaporated. Purification by flash column chromatography (toluene/ethyl acetate 15:1) provided methyl ester 54 (56 mg, 100%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07671032B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-27393fcdb616489db3315c6d4915d2d1 |
| Source note | uspto-grants-2010_03 |