Water → HCID 59205673, compound

Participants

Reaction Steps

A stirred solution of 15.0 grams (0.056 mole) of 2,6-dichloro-4-(phenylmethoxy)phenol (known compound) and 15.0 grams (0.109 mole) of potassium carbonate in 200 mL of DMF was cooled to 0-4° C. and 8.4 grams (0.067 mole) of 2-bromoethan-1-ol was slowly added. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it was stirred during an 18 hour period. After this time water was added to the reaction mixture, and the mixture was extracted with two 150 mL portions of diethyl ether. The combined extracts were dried with sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to yield 17.1 grams of residual oil. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence