HCID 11619385, compound → HCID 11669341, compound

Participants

Reaction Steps

To a solution of 35 (0.1 g, 0.22 mmol, 1.0 eq) in tetrahydrofuran (10 mL) under nitrogen at 0° C. was added lithium aluminum hydride (1.0 M in THF, 1.76 mL, 1.76 mmol, 4.0 eq). The mixture was slowly warmed up to room temperature over 2.5 hours. The reaction was quenched with ice chips, and then water and ethyl acetate were added. The aqueous layer was extracted with ethyl acetate (2×20 mL), and the combined organic layer was washed with water (20 mL), brine (20 mL) and dried over anhydrous MgSO4 The solvent was removed under reduced pressure, and the residue was purified by column chromatography (silica gel, 2-10% methanol in dichloromethane).

Provenance & Evidence